One of the original Twelve Apostles of Jesus, Bartholomew allegedly met his martyred end in Albanopolis, Armenia during the first century. By some accounts, he was merely beheaded, but popular tradition holds that he was flayed alive and crucified upside-down.
You'll also spot his flayed skin in Michelangelo's The Last Judgment, pictured to the left. Interestingly enough, depictions of the saint often echo that of the Greek hero Hercules, who often holds the skin of the Nemean Lion.